- 향후 5년 ‘제2형 당뇨병’ 발병 예측
- 개인 맞춤형 조기 진단 및 예방책 도출 기대

[Hinews] SEOUL, South Korea — A research team at Korea University Anam Hospital has developed an innovative diabetes prediction system that integrates clinical and genetic data to assess disease risk, securing a domestic patent for a breakthrough in personalized medicine for type 2 diabetes.

Led by Dr. Nan-Hee Kim from the Department of Endocrinology and Metabolism, alongside Drs. So-Young Park, Min-Hee Kim, and Jae-Young Kim, the team designed the system to forecast diabetes risk using clinical metrics and ethnicity-specific genetic markers.

Type 2 diabetes, accounting for 90% of diabetes cases, stems from insulin resistance driven by a mix of genetic predisposition and environmental factors such as aging, obesity, certain medications, and stress. With treatment challenging and complications severe, prevention is paramount. The researchers believe their system could facilitate tailored early interventions by incorporating both environmental and genetic risk factors into clinical practice.

Photo: From left, Drs. Nan-Hee Kim, So-Young Park, Min-Hee Kim, and Jae-Young Kim of Korea University Anam Hospital. (Courtesy of Korea University Anam Hospital)
Photo: From left, Drs. Nan-Hee Kim, So-Young Park, Min-Hee Kim, and Jae-Young Kim of Korea University Anam Hospital. (Courtesy of Korea University Anam Hospital)

The system comprises five components: a database module to collect and manage clinical and genetic data; a data processing unit to analyze the frequency of genetic variants from ethnicity-specific datasets; a prediction module to estimate the five-year risk of diabetes onset; an analysis unit to identify contributing risk factors; and a reporting module to generate personalized diagnostic and preventive recommendations.

Clinical data includes fasting blood glucose levels, dietary habits, and obesity indicators, while genetic data focuses on risk alleles linked to heightened type 2 diabetes susceptibility.

“This system delivers precise risk assessment by combining personal, genetic, and lifestyle factors,” Dr. Kim said. “It allows us to pinpoint high-risk periods for diabetes onset, enabling timely preventive measures.”

The team is based at Korea University Anam Hospital and its Biomedical Research Center. Drs. Kim and Park are from the Department of Endocrinology and Metabolism, while Drs. Min-Hee Kim and Jae-Young Kim are affiliated with the Biomedical Research Center.

키워드

#당뇨병#당뇨병진단#당뇨병검사#제2형당뇨병#인슐린저항성
저작권자 © Hinews 무단전재 및 재배포 금지
ad